Structural biologists Greg Petsko has been writing a thought-provoking and entertaining monthly column in the scientific journal Genome Biology every month since its launch in June 2000. The first 10 years of these columns are compiled in this collection."An addictive series of science OP-ED commentaries... using current issues to illuminate issues important in the profession and in the relationship of science to society"Virginia Walbot"If only the people who ran our nations had the Petsko combination of wit and sense..."David Baulcombe"Petsko can always be counted on to leave me with a smile while offering a fresh perspective on issues facing the genome biologist, be they trends in genomics research, scientific interaction in the age of social networking, science policy in our politicized era, or life science funding"Marc S. Halfon"As no other, Petsko knows how to place modern biology into the larger picture of today's society. A welcome and often brilliant view"Alex Griekspoor"Elegantly phrased, witty, original and always to the point, the Petsko columns set the ultimate standard for fellow-columnists like me." Piet Borst